Managing Severe Asthma: A Role for the Long-Acting Muscarinic Antagonist Tiotropium.

Biomed Res Int · 2018 · PMC6220412 · PMID 30474042

Europe PMC DOI

hedged sentences

0.0460

closest p · 0.9× alpha

0.0600

boldest claim

The sentences

nominally significantP=0.046actually significant

However, the lower dose of tiotropium 2.5 μ g did show nominally significant improvement in peak FEV 1(0–3h) response versus placebo add-on at Week 12 (111 mL, 95% CI 2–220, P=0.046).

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did not reach statistical significanceP=0.06so close (0.05 < p ≤ 0.1)

Trial 2 of PrimoTinA-asthma showed a significant improvement in patients' seven-question Asthma Control Questionnaire (ACQ-7) score (–0.2, P=0.003), even though the effect in trial 1 did not reach statistical significance (–0.13, P=0.06).

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