Tumor Necrosis Factor Inhibitor Discontinuation in Patients with Ankylosing Spondylitis: An Observational Study From the US-Based Corrona Registry.

42.7 [28.9]) compared with those in the continued cohort, although these differences did not reach statistical significance ( P = 0.42 and 0.10, respectively) (Table 3 ).

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A prospective, observational study of TNFi-naive patients with AS who initiated a TNFi in the South Swedish Arthritis Treatment Group Register also identified absence of peripheral arthritis as a significant predictor of TNFi discontinuation and showed a trend toward greater likelihood of TNFi discontinuation in patients with lower CRP levels and use of TNFi without a csDMARD; however, no association was found between disease activity measures including BASDAI, BASFI, and investigator’s global assessment and the likelihood of TNFi discontinuation [ 43 ].

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