Efficacy of a Postprescription Review of Broad-Spectrum Antimicrobial Agents With Feedback: A 4-Year Experience of Antimicrobial Stewardship at a Tertiary Care Center.

Although the monthly average use of both carbapenems and piperacillin/tazobactam was lower in the intervention period (8.67 and 20.95 DOT per 1000 PD), the change in the slope for carbapenem use significantly diminished, showing a leveling-off effect (from −0.73 to −0.003 DOT per 1000 PD [ P < .001]), and that for piperacillin/tazobactam did not reach statistical significance (−0.04 to −0.24 DOT per 1000 PD [ P = .16]).

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Similarly, although piperacillin/tazobactam use failed to reach statistical significance, sustained reduction continued to be observed in the intervention period.

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