Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.

Of the four SNPs with significant or borderline significant IL-2 associations in the whole blood assay, only rs10507173 was associated with CD4+ IL-2 production ( p <0.0001, general linearized model), though the association was driven by a single minor allele homozygote outlier (2H) and was not significant under a dominant model ( p = 0.95).

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SNPs rs10507172, rs10507173, and rs1920413 showed significant or near-significant associations with TB disease using a dominant model in an unadjusted analysis ( i . e . comparing AA vs Aa/aa; p = 0.036, p = 0.025, and p = 0.069, respectively).

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SNPs rs10507172 and rs10507173 were associated with IL-2 production ( p = 0.002) while two other SNPs (rs1305392 and rs1920413) showed a trend towards association with IL-2 production ( p = 0.055 and 0.080, respectively) (general linearized model, Fig 2A, 2C, 2E and 2G ).

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Second, the TB case-control data became more highly significant when using strict criteria for the diagnosis of TB disease.

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