Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex.

Although OSS led to a clear trend of orientation dependence of the activation, no statistically significant differences were reached in CP (0°, 60°–120°, −90°, −60°; p FDR = 0.086) or LS (0°–60°, −120°, −60°, −30°; p FDR = 0.086), while the IL and NAc showed virtually no dependence on stimulation angle with no statistically significant differences.

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The ROI analysis of the OSS-fMRI responses confirmed statistically significant differences in the number of activated pixels observed with different orientations, although differences in amplitude of the fMRI responses did not reach statistical significance.

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