Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice.

Summary data illustrated that the lower dosage of cANF (0.07 mg/kg/day) did not prevent Ang II-mediated changes in HR (p = 0.915) ( Figure 5B ); however, there was a clear trend toward a reduction in cSNRT (p = 0.067) ( Figure 5C ) compared with Ang II alone.

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Furthermore, CV in the right atrial posterior wall following treatment with the low dosage of cANF tended to be higher than that of Ang II alone, but this did not reach statistical significance.

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