Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma.

PLoS One · 2019 · PMC6319703 · PMID 30608927

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showed a trendno p-value reported

In the spines, bolus IVT topotecan showed a trend towards slower tumor growth compared to continuous (pump) IVT topotecan, as measured by bioluminescence.

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did not reach statistical significanceno p-value reported

Spine tumor progression in mice receiving topotecan IVT by bolus showed a trend towards slower tumor growth compared to those receiving it by pump but did not reach statistical significance ( Fig 4C ).

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