The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.

However, even nominally significant associations would not remain significant after Bonferroni correction, pointing to the need of large, well-characterized cohorts for studying the important questions of IBD genetic risk and disease course and treatment.

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In agreement with this notion, carriers of the rs8005161 T allele developed disease 1.3 years before rs8005161-CC carriers; however, probably due to the wide distribution of the year of onset of disease, this difference failed to reach statistical significance.

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