RGS9-2 rescues dopamine D2 receptor levels and signaling in <i>DYT1</i> dystonia mouse models.

EMBO Mol Med · 2019 · PMC6328939 · PMID 30552094

Europe PMC DOI

hedged sentences

0.2232

closest p · 4.5× alpha

0.2232

boldest claim

The sentences

showed a trendP = 0.2232not close (p > 0.1)

WB of dorsal striatum lysates showed a trend for an increase in LAMP‐2 levels in mutant mice (Fig 3 G; Tor1a +/+ 1.000 ± 0.104 N = 8; Tor1a +/− 1.168 ± 0.058 N = 6; t ‐test P = 0.2232).

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did not reach statistical significanceno p-value reported

The observation that changes in basal LC3‐II, p62, and LAMP‐2 levels did not reach statistical significance rules out an overt dysregulation of autophagy and supports a more confined impairment involving targeting of DRD2 to degradation.

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