Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease.

Although the number of infiltrated neutrophils and macrophages (Figure 4C ) and HE-scoring of hepatic inflammation (Figure 3C and Supplementary Figure S6 ) did not reach statistical significance between study groups, a trend toward reduction of these parameters following immunization was observed.

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Seven week-old Npc1 nih mice that received the immunization demonstrated reduced levels of hepatic total cholesterol (Figure 3A ) and triglycerides (Figure 3B ) compared to control-treated Npc1 nih mice, though the latter only showed a trend.

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