Liver DNA methylation of FADS2 associates with FADS2 genotype.

Clin Epigenetics · 2019 · PMC6337806 · PMID 30654845

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borderline significantno p-value reported

In this preliminary analysis, we observed that there was a borderline significant association between methylation levels of cg06781209 and erythrocyte folate levels (nominal p value of 0.050 in ANOVA, Additional file 8 ).

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did not reach statistical significanceno p-value reported

Spearman correlation analysis showed that both cg06781209 and cg07999042 associated negatively with the grade of steatosis in liver ( n = 72, nominal p < 0.05 for both, Additional file 5 ), but the correlation did not reach statistical significance after correcting for multiple testing (FDR 0.25).

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nominally significantno p-value reported

We observed a nominally significant correlation between methylation levels of cg06781209 and levels of erythrocyte folate (nominal p value of 0.025, Spearman correlation, Additional file 5 ), but the association did not remain significant after correcting for multiple testing.

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