IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8⁺ T Cell Priming.

The cancer cell lysate also induced expression of additional targets of the UPR in FL-DCs such as the ER chaperone BiP (Figure 1B ) and showed a trend in the induction of CHOP , a transcriptional regulator activated downstream of PERK (Figure 1B ).

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The induction of the additional XBP1s target gene Sec61a did not reach statistical significance, indicating that MEL lysates do not induce the full XBP1s transcriptional program.

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