Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism.

36 A component of the high affinity manganese transporter, MntC, which is regulated by the manganese sensor MntR, 37 also appeared to be induced under the copper treatment conditions, although this did not reach statistical significance (see full results table, provided as ESI † ).

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However, we noted that the inducible superoxide dismutase enzyme, SodM, was significantly induced 6.7-fold by 2.5 mM Cu in TSB relative to control (and was induced under all other copper treatments but failed to reach statistical significance).

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