Arteries from Prog-Tg animals showed a trend toward delayed response to Ach at lower Ach concentration, but not to SNP, with slightly reduced pEC 50 values ( Supplemental Figure 3 ), indicating a prolonged lag phase in endothelium-dependent vessel relaxation in Prog-Tg animals.
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Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse.
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A similar MRTFA-dependent increase was observed for Col1 expression, although it did not reach statistical significance (data not shown).