Moreover, in the range of the physiological membrane potential (i.e., at 0 mV clamp voltage, see below), TTFields increased (T98G cells) or showed a trend to increase (U251) the membrane conductance of the clamped membrane area ( Figure 3 D) suggesting that TTFields may interfere with the physiological electrosignaling of glioblastoma cells.
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Alternating Electric Fields (TTFields) Activate Ca<sub>v</sub>1.2 Channels in Human Glioblastoma Cells.
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The I/V curves in Figure 3 C especially in U251 cells also show a trend to TTFields-stimulated inward currents which, however, did not reach statistical significance.