IL1RL1 is dynamically expressed on Cbfb-MYH11<sup>+</sup> leukemia stem cells and promotes cell survival.

Interestingly, the less proliferative populations showed a trend towards increased relative viability when treated with DOXO, although this difference was not statistically significant (Fig. 4B ).

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Starting on day 7, we observed a smaller population of IL1RL1, CSF2RB double positive (CSF2RB + IL1RL1 + ) cells, and this population continued to increase through day 20, but did not reach statistical significance as compared to the control mice (Fig. 1B,C ).

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