Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia.

Similarly, a multivariate association test focused on the three RAN traits revealed a genome-wide significant association of rs17663182 ( p = 1.15 × 10 −8 ), while rs16928927 association only approached significance ( p = 5.45 × 10 −8 ).

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The SNPs showing the largest allele frequency differences between low- and high-ability groups were tested in an additional follow-up cohort of 4258 children, finally identifying 10 SNPs showing nominally significant associations with continuous variation in reading ability 34 .

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