Effect of the live oral attenuated typhoid vaccine, Ty21a, on systemic and terminal ileum mucosal CD4+ T memory responses in humans.

However, we found that the frequencies of CCR9 + CD4 + T cells in LPMC showed a trend ( P = 0.15) to be higher than their PBMC counterparts following Ty21a immunization ( Fig. 2B ).

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In this study, we observed that the homing patterns and net CMI responses were markedly increased in some individuals, but as a group did not reach statistical significance, likely because of the relatively limited number of participants evaluated.

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