Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.

PLoS One · 2019 · PMC6386446 · PMID 30794604

Europe PMC DOI

hedged sentences

0.0696

closest p · 1.4× alpha

0.0957

boldest claim

The sentences

approached significancep = 0.0696so close (0.05 < p ≤ 0.1)

Examination of lung pathology on day 9 showed that Myd88 -/- mice had slightly reduced overall lung pathology that approached significance (p = 0.0696) compared to WT mice ( Fig 4C ).

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did not reach statistical significancep = 0.0957so close (0.05 < p ≤ 0.1)

However, there was a trend for Nlrp3 -/- mice toward lower bacterial burden in the lungs, but this did not reach statistical significance compared to WT mice (p = 0.0957) ( Fig 4B ).

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