Complement system biomarkers in first episode psychosis.

The association of FEP with sex, ethnicity, tobacco and cannabis consumption was assessed using Chi-square tests; all four of these categorical variables showed significant or near-significant effect (sex, p < 0.005; ethnicity, p < 0.07; tobacco, p < 0.00005; cannabis, p < 0.04).

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The chosen model (Model B) revealed, after stepwise selection, two complement proteins, C3 and C4, as significantly different between the FEP and control groups, with four complement analytes (C5, TCC, C1 inhibitor and FHR125) trending towards significance and strengthening the model.

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