Closure of the Human TKFC Active Site: Comparison of the Apoenzyme and the Complexes Formed with Either Triokinase or FMN Cyclase Substrates.

Int J Mol Sci · 2019 · PMC6429413 · PMID 30836629

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a marked trendno p-value reported

Conclusions Computational evidence supports a marked trend of hTKFC:2DHA:2ATP, i.e., the complex typical of the DHA kinase activity of hTKFC, towards active-site closure in one of the two sites displayed by the dimeric enzyme.

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a clear trendno p-value reported

The analysis of normal modes showed a clear trend of the open conformation of hTKFC to progress towards a less open conformation.

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