The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.

In a multivariate analysis after adjustment for the ISS, the per-patient guideline adherence rate was a highly significant factor for a decreased mortality at 30 days (OR 0.47 (0.31–0.72, p = 0.0004) [ 41 ].

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However, a significant reduction in the requirement of RBC transfusions (22.8 ± 8.1 units vs 17.6 ± 7.6 units) was observed ( p = 0.003) as well as a faster correction of laboratory coagulopathy upon ICU admission for fibrinogen and Quick value and a clear trend to better results for INR and PTT.

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However, on hospital arrival, the patients receiving a vasopressor had a much lower GCS and a higher lactate level and showed a trend toward the transfusion of more blood products.

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