After adjusting by age, route of HIV infection, length of infection before cART and viral hepatitis coinfection, CCR2 rs1799864-AG genotype was significantly associated with INR status (OR [95% CI]: 1.80 [1.04–3.11]; p = 0.04), and CXCL12 rs1801157-TT genotype showed a trend (OR [95% CI]: 2.47 [0.96–6.35]; p = 0.06).
However, after correcting by age, length of infection, co-infection with hepatitis viruses and transmission route, variables that presented significant differences between INR and IR groups ( Table 1 ), the multivariate logistic analysis showed that CCR2 rs1799864 AG genotype was significantly and independently associated to INR status (OR: 1.80 [1.04–3.11]; p = 0.036) and CXCL12 rs1801157 TT genotype showed a clear trend (OR: 2.47 [0.96–6.13]; p = 0.063) ( Table 3 ).