Shortened up-dosing with sublingual immunotherapy drops containing tree allergens is well tolerated and elicits dose-dependent clinical effects during the first pollen season.

In patients who started the therapy two months before the start of pollen season, the difference versus placebo in this score did not reach statistical significance. 36 This is highlighted by the subgroup analysis in our study that took the patients who were treated late in the study (co-seasonal) as a control group due to the lower cumulative dose administered.

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Local (pharyngeal) reactions The proportion of patients who did not report any local reaction in the patient diary was comparable between the up-dosing groups during the up-dosing phase: 50.8% in the conventional, 45.5% in the ultra-rush office-based, and 51.9% in the rapid home-based group, whereas the conventional group showed a trend towards a greater intensity of adverse events (AEs) than did the other groups ( Fig. 4 a).

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