Effects of Vitamin E-Stabilized Ultra High Molecular Weight Polyethylene on Oxidative Stress Response and Osteoimmunological Response in Human Osteoblast.

In our study, RANKL/OPG ratio showed a trend toward an increase in this ratio when UHMWPE is not stabilized with Vitamin E, while the addition of Vitamin E restores the bone turnover stimuli to levels comparable to controls.

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Statistical analysis was performed with one-way ANOVA, considering p < 0.05 as significant and p < 0.001 as highly significant.

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This effect attenuates at 48 h, resulting in an insignificant difference between M1 and M2, maintaining a low but weakly significant level in response to M3.

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