Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression.

In contrast, the absolute tumor size was reduced in mice treated with 12 mg/kg paclitaxel compared with that in mice treated with vehicle, but the difference did not reach statistical significance ( P = 0.564).

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Similarly, the difference in tumor size failed to reach statistical significance when comparing the treatment of xenograft mice with 5 mg/kg SC66 + 12 mg/kg paclitaxel or 15 mg/kg SC66 + 12 mg/kg paclitaxel compared with that of mice treated with only 12 mg/kg paclitaxel ( P = 0.083 and P = 0.083, respectively).

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