Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test.

PLoS One · 2019 · PMC6464213 · PMID 30986274

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.1400

boldest claim

The sentences

a statistical trend toward significancep = 0.056so close (0.05 < p ≤ 0.1)

Swimming (mobile) behavior was not affected by this drug ( S1B Fig , p > 0.05), whereas immobility ( S1C Fig ) decreased with all mice included (t = 2.30, df = 14, p < 0.05), and showed a statistical trend toward significance with the outlier mouse excluded (t = 2.09, df = 13, p = 0.056).

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approached significancep = 0.075so close (0.05 < p ≤ 0.1)

When two mice that were > 2 standard deviation outliers were removed ( S2 Fig , middle column), the one-way ANOVA for swimming approached significance [F(2,19) = 2.98, p = 0.075].

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did not reach statistical significancep > 0.14not close (p > 0.1)

There was a statistically significant positive correlation between these two tests for unstressed vehicle mice (r = 0.73, p = 0.041), but for each of the 8 other stress x drug combinations, the correlation did not reach statistical significance (p > 0.14 in each case).

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