In detail, the disease was protracted and showed a trend to increased severity in SJL/J EAE mice but was ameliorated in the C57BL/6 background.
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The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis.
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In the late phase (days 16–30 pI), we observed more severe disease in the SMK vs CTRL, however, this difference did not reach statistical significance ( Figure 4 e).