Who benefits from percutaneous closure of patent foramen ovale <i>vs</i> medical therapy for stroke prevention? In-depth and updated meta-analysis of randomized trials.

Compared to medical therapy, PFO closure showed a reduction in stroke risk in females [0.50; 0.23-1.08; P = 0.08; I 2 = 0%] and patients > 45 years of age [0.32; 0.10-1.06; P = 0.06; I 2 = 52%]; however, it did not reach statistical significance.

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In females and persons > 45 years of age, there was a strong trend towards reduction in stroke risk, but it did not reach statistical significance.

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