Diagnostic performance of the specific uptake size index for semi-quantitative analysis of I-123-FP-CIT SPECT: harmonized multi-center research setting versus typical clinical single-camera setting.

The difference was highly significant for both SUSI and SBR (e.g., multi-site/multi-camera setting: putaminal SUSI = 0.993, striatal SUSI = 0.978, p < 0.001, Table 1 ).

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However, direct statistical comparison of the AUC difference between the SUSI and the SBR between the MULTI setting and the MONO setting showed a trend toward larger AUC difference in the MULTI setting compared to the MONO setting ( p = 0.073, Fig. 6 ), supporting the primary hypothesis.

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Stereotactical normalization prior to ROI analysis improved the performance of the putaminal SUSI from AUC = 0.961 to AUC = 0.969, but the difference did not reach statistical significance ( p = 0.129, Table 1 ).

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