An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.

Effects of twice-daily administration of (DAla 2 )GIP and (DAla 2 )GIP/xenin-8-Gln on glucose tolerance and metabolic response to GIP in high-fat-fed mice Treatment with (DAla 2 )GIP or (DAla 2 )GIP/xenin-8-Gln for 21 days reduced overall AUC for blood glucose levels of high-fat-fed mice following a glucose load but the difference failed to reach statistical significance (Table 1 ).

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Mice treated twice daily with either (DAla 2 )GIP or (DAla 2 )GIP/xenin-8-Gln did have reduced plasma insulin levels compared with high-fat-fed controls on day 21 but the difference did not reach statistical significance (Fig. 3f ).

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