Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer.

LG), gender and age, THOR high / TERT p Mut also displays a trend toward significance (HR: 3.32, CI 95% 0.99–11.16; p = 0.05) (Supporting Information Table S5 ).

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17 , 18 , 25 However, TERT p Mut status did not reach statistical significance with respect to the risk of progression to invasive disease ( p = 0.052) (Fig. 2 b , Table 2 ). 17 , 18 As for TERT p Mut , THOR high NMIBC recurred more frequently (HR: 1.5, 95% CI 1.02–2.20; p = 0.03; Table 2 ), with decreased median disease‐free survival (76 months vs . 31.7 months) (Log rank p = 0.034; Fig. 2 c ).

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Furthermore, since large numbers of tumors are necessary for survival analysis in NMIBC, in our multivariate analysis THOR High /TERTp Mut only showed a trend toward significance as a risk factor for disease progression.

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