Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.

Although the experiments performed in Nlrp3 −/− mice did not reach statistical significance, there was a trend toward lower survival in those mice when treated with anti-CTLA-4 or anti-PD-1 mAb ( Figure 3 C).

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Moreover, in vitro re-stimulation of TDLN cells with ovalbumin (OVA) showed increased proportion of IL-17 + CD4 + T cells in Tmem176b −/− compared with WT mice ( Figure S2 K), and in vivo IL-17A blockade showed a clear trend toward suppression of the antitumor effect in tumor-bearing Tmem176b −/− mice ( Figure S2 L).

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