Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants.

Genes (Basel) · 2019 · PMC6523194 · PMID 30987408

Europe PMC DOI

hedged sentences

0.0460

closest p · 0.9× alpha

0.0460

boldest claim

The sentences

showed a trendp = 0.046actually significant

GSTA1 variant (12.8% of patients) showed a trend ( p = 0.046, LME) for an association with decreased clinical efficacy; however, no significant effect on azathioprine pharmacokinetics could be detected.

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not fully significantno p-value reported

Considering studies by other groups, our results are in agreement with a recently published paper describing a lower efficacy of azathioprine in patients with GSTM1 deletion, even if the results were not fully significant [ 28 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.