Nine-year analysis of isolated pathogens and antibiotic susceptibilities of microbial keratitis from a large referral eye center in southern China.

Among 319 dual-positive specimens, the most common bacterial component was Staphylococcus epidermidis (n=137, 42.95%), and the most frequent fungus detected was Fusarium species (n=118, 36.99%) ( Table 3 ). As shown in Figure 1 , there was a significant trend of decline in the number of isolates of Gram-positive cocci (r =−0.711, P =0.032) recovered during the study period.

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In contrast, an increasing trend in the proportion of Gram-negative bacilli was observed (r=0.661, P =0.053).

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Conclusions During the period from 2010 to 2018, the proportion of Gram-positive cocci (mainly CNS) isolated from cases of keratitis comprised the majority, yet showed a trend of decline, whereas Gram-negative bacilli are suspected to be increasing in number at the largest eye center in southern China.

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