Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease.

However, whereas cells treated with only TTX had increased mean mEPSC frequency relative to those treated with vehicle control ( ∗∗∗ p < 0.001), the difference in mean mEPSC frequency between cells treated with both TTX and pridopidine or with pridopidine alone did not reach statistical significance ( p = 0.06), suggesting an attenuated effect of TTX on mEPSC frequency ( Figure 4C and Supplementary Figure S2B ).

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After 48 h of TTX treatment, cultured CPNs from WT FVB/N mice showed increased mEPSC frequency and a strong trend, which was significant in some sets of experiments, toward increased mEPSC amplitude.

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