Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection.

We first observed that TCM display less CXCR6+ cells than TTM with a highly significant difference (median 2.8% versus 4.3%, respectively; p = 0.001) ( Fig 8A ).

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HIV-2 DNA levels in TTM cells showed a trend towards a correlation with the TCM infection levels (p = 0.05; r = 0.54) ( Fig 3A ) and were correlated to HIV-2 total DNA in PBMC (p = 0.01; r = 0.66) ( Fig 3B ) while HIV-2 DNA levels in TCM were not ( Fig 3D ).

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This analysis, despite of limited samples size, clearly demonstrates that HIV-2 reservoirs have different characteristics from the HIV-1 reservoirs by a total lack of monocytic infection and a strong trend towards a predominance of the infection in TTM instead of TCM cells.

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