IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer.

1.9 ± 2.3; p < 0.05), but this difference did not reach statistical significance, probably as a consequence of the small sample size and the high variation of IGF2 levels within the tumor samples.

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Additionally the combined treatment with linsitinib and sirolimus showed a trend to have additive effects in inducing G1-cell cycle block.

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