Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.

There were, however, highly significant differences between groups in the extent of this decline ( p < 0.0001 for the interaction between treatment and time, see Fig. 1 A).

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Animals receiving 1.0 mg/kg pridopidine showed a trend towards an improved stepping performance during the last 2 weeks, but the difference from saline-treated mice did not reach significance (Fig. 1 C, cf. pridopidine-1 and saline group in week 5, ~ 49% and ~ 63% difference vs sham, respectively, p < 0.05).

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Mice treated with 1 mg/kg pridopidine showed a trend towards an increase that did not reach statistical significance (Fig. 2 J).

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