a negative trendp = 0.512
In addition, plasma CTHRC1 showed statistically significant positive correlation with RF (ρ = 0.596, p < 0.0001, Figure 5E and Table 1S ) and ACPA (ρ = 0.35, p = 0.008, Figure 5F and Table 1S ), but not with ESR, which exhibited a negative trend that did not reach statistical significance (ρ = −0.088, p = 0.512, Figure 5D ; Table 1S ).