Although the mean average was higher in AAV9 Tau ΔD421 mice, OAZ1 failed to reach statistical significance (Fig. 6 c).
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Spermidine/spermine-N<sup>1</sup>-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
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Importantly, AAV9 Tau ΔD421 increased acetylspermidine and showed a trend toward increased putrescine whereas SSAT deficiency prevented these effects (Fig. 7 a, d).