Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma.

Nat Commun · 2019 · PMC6611767 · PMID 31278276

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did not reach statistical significanceno p-value reported

1d ), although the difference did not reach statistical significance, probably due to small sample size, low TMB, and substantial heterogeneity in this cohort of IPNs.

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showed a trendno p-value reported

Smokers also showed a trend of higher clonal TMB (Supplementary Fig. 10c ), higher subclonal TMB (Supplementary Fig. 10d ) and higher proportion of trunk mutations (Supplementary Fig. 10e ).

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