Intranasal Administration of Mesenchymal Stem Cells Ameliorates the Abnormal Dopamine Transmission System and Inflammatory Reaction in the R6/2 Mouse Model of Huntington Disease.

In comparison with WT-PBS, NGF was downregulated in all investigated brain regions of R6/2-PBS mice although the decrease did not reach statistical significance in cortex and striatum.

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Two-way-ANOVA analysis revealed no significant difference among the 3 treatment groups, although R6/2 mice with PBS or MSCs treatment showed a trend of reduced body weight at 11 weeks of age when compared to WT controls ( Figure 2 B).

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