Impact of molecular subtypes on the prediction of distant recurrence in estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer upon five years of endocrine therapy.

However, as shown by the wider CIs (0.041–1.015) and by the marginally significant p -value (0.052), this association lacked the strength observed over the entire follow-up period.

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In multivariable analysis in the ESR1+/ERBB2- set the MKI67 status and tumor stage displayed almost identical hazard ratios, however only stage was clearly significant (Table 6 ).

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In the present study, Luminal A-like tumors demonstrated a trend towards improved outcomes in the late follow-up period; however, results did not reach statistical significance.

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