Augmentation of myocardial I<sub>f</sub> dysregulates calcium homeostasis and causes adverse cardiac remodeling.

Nat Commun · 2019 · PMC6650438 · PMID 31337768

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did not reach statistical significanceno p-value reported

2j, k ), although these changes did not reach statistical significance.

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showed a trendno p-value reported

Furthermore, levels of transcripts of the repolarizing channel genes KCNQ1 ( encoding Kv7.1) and KCND2 (encoding Kv4.2) were decreased, while the repolarizing channel gene KCNH2 (encoding Kv11.1) showed a trend toward higher levels (Fig. 4e ).

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