Although pharmacological inhibition of sEH showed a trend to limit mitochondrial expression of Mfn-2, it did not reach statistical significance compared to WT IR hearts ( Figure 6 B).
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Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation.
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