However, all of the three lipofuscin compounds analyzed showed a trend towards higher concentration in aged B6/J +/N and N/N mice compared to age-matched B6/J +/+ controls, although concentrations varied considerably among the elder group while data failed to reach statistical significance.
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The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.
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