Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2<sup>+ve</sup> breast cancer metastasis.

Breast Cancer Res · 2019 · PMC6693253 · PMID 31409375

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a strong trendno p-value reported

Further analysis of markers of iron metabolism/ferroptosis in TBCP-1 tumours revealed increased levels of ferritin ( p < 0.05) and a strong trend towards decreased ferroportin-1.

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did not reach statistical significanceno p-value reported

Transferrin receptor-1, the main cellular iron (Fe 3+ ) importer, increased ~ 2-fold after exposure to neratinib, but this response was variable and did not reach statistical significance.

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