18 19 Using PET, a study of 10 controls and 22 patients with CKD stages 3–5 showed a trend towards reduced CFR with increasing stage of CKD, but this did not reach statistical significance. 20 Similarly, retrospective calculation of CFR using PET in 435 patients with stages 1–3 CKD also found there was no significant difference in CFR after correction for cardiovascular risk factors such as age, sex and blood pressure. 21 The largest PET study to date is a retrospective analysis of 3946 patients who underwent stress PET at a single US institution.
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Coronary microvascular dysfunction: a key step in the development of uraemic cardiomyopathy?
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