Selective activation of G_s signaling in adipocytes causes striking metabolic improvements in mice.

CNO-treated adipo-GsD mice showed a trend towards reduced food intake, bust this effect failed to reach statistical significance ( Figure 1 J). 3.4 Metabolic studies with mice consuming an obesity-inducing diet We next carried out metabolic studies with mice that had been maintained on a high-fat diet (HFD) for at least 8 weeks ( Figure 2 A).

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